Postdoctoral researcher at Northeastern University studying natural bioactive compounds and their roles in inflammation, neurodegeneration, and cancer.
CV:
Dr. Evangelos (Vaggelis) Dadiotis is a postdoctoral researcher in Pharmacognosy and Ion Channel Pharmacology, currently based at Northeastern University in Boston, USA. He holds a PhD in Pharmacy from the National and Kapodistrian University of Athens, specializing in natural product chemistry and bioactive secondary metabolites. His research focuses on olive oil phenolics and cannabinoids as modulators of cellular signaling pathways, particularly the TRPA1 system. Using electrophysiology, calcium imaging, and analytical chemistry, his work explores the molecular mechanisms linking natural products to inflammation, neurodegeneration, and cancer, aiming to bridge traditional Mediterranean bioactives with modern biomedical research.
Presentation title:
Oleocanthal and the Body’s Stress Sensors: Implications for Inflammation and Disease
Presentation abstract:
Oleocanthal, the phenolic responsible for extra virgin olive oil’s pungent taste, interacts with the TRPA1 ion channel, linked to inflammation, neurodegeneration, and cancer. Using calcium imaging, patch-clamp, and molecular methods, we study how oleocanthal and its metabolites activate and modulate TRPA1. It initially activates then desensitizes the channel, suggesting a dual role that may underlie its protective effects. This presentation links olive oil chemistry to modern mechanistic insights into health and disease.